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Making use of the Food and Drug Administration briefing documents to reconsider the safety of the antipsychotic sertindole

2 Sep

Sertindole (Serdolect in the world, Zerdol in Germany) is an atypical antipsychotic agent, schizophrenia. Sertindole side effects include cardiac problems as prolongation of QT interval, arrhythmia and sudden deaths (higher than for other atypical antipsychotics). The FDA analysis of SCoP, made public in April 2009, estimated the hazard ratio for sudden cardiac death with sertindole [...]

Overdiagnosis as an extreme form of length-time bias. Breast cancer screening as an example

14 Oct

Overdiagnosis is an error of prognosis. Overdiagnosis is not an error of diagnosis. Overdiagnosis is a “true positive” diagnosis. We cannot distinguish between overdiagnosis cancer and non-overdiagnosis cancer. In this presentation the focus is on the vision of overdiagnosis as extreme form of length-time bias, and the research lines which might help in the future [...]

Minimum data set in General Practice: definitions and coding

31 Jan

A minimum basic data set (MBDS) was designed and used in general practice. The most important purpose and need for establishing such a data set is to assist in the provision of patient care. MBDS is designed to meet common needs for many general practitioners. Minimum means that individual programmes or the GP are free [...]

Trials of improve care for the elderly

7 Mar

Clinical randomized trials are experimental situations where some patients might received excellent care. What happens after the end of the trial? This a key ethical question should be answered in all proyects and programs of clinical trial.  Trials of improve care for the elderly. Gérvas, J., Pérez Fernández, M. N Engl J Med. 1996; 334: [...]

Logical graphical representation of medical activity

20 Dec

The health system has four functions: 1/ health protection, 2/ health promotion, 3/ health prevention, and 4/ care of diseases and helping to die. In this text there is a proposal for a graphical representation that helps in understanding the medical activity. Logical graphical representation of medical activity. Gérvas, J. Diciembre 2011. Download English version here.

Quaternary prevention: theory and practice

13 Oct

All health services have adverse effects, all health services might produce damage to health. A few services produce more benefits than harms in specific situations. Unnecessary and inappropriate services mainly produce harms, and few benefits if any. Quaternary prevention is the prevention of unnecessary and/or inappropriate services and the prevention of over-medicalisation. Quaternary prevention refers mainly to personal services, [...]

Critical steps in Europe to set up PHC under conditions of resource constraint. The case fo the Mediterranean countries

21 Sep

Primary health care have a different status across countries. This paper is an exploration of the reasons why. Much can be learned by analysing Spain as a benchmark, and comparing it with other Mediterranean countries (Greece, Italy, and Portugal). Critical steps in Europe to set up PHC under conditions of resource constraint. The case fo the [...]