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Making use of the Food and Drug Administration briefing documents to reconsider the safety of the antipsychotic sertindole

2 Sep

Sertindole (Serdolect in the world, Zerdol in Germany) is an atypical antipsychotic agent, schizophrenia. Sertindole side effects include cardiac problems as prolongation of QT interval, arrhythmia and sudden deaths (higher than for other atypical antipsychotics). The FDA analysis of SCoP, made public in April 2009, estimated the hazard ratio for sudden cardiac death with sertindole [...]

Ovarian cancer screening: could you recommend it? No

15 Aug

In December 2015, The Lancet published the final results of The UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)  which “was designed to determine how many lives could be saved by screening for ovarian cancer”.  The UKCTOCS is another ovarian cancer screening that demonstrates that screening did not reduce  ovarian cancer specific mortality neither all-cause [...]

Ten commandments for the rational use of vaccines. November 2015

1 Nov

Vaccines are a treasure that is not defended and it is improved by simply repeating that mantra. The vaccine treasure requires good use and a continuous critical evaluation, in relation to developing and maintaining the vaccination schedules. Vaccination policies have been very poor in the recent decades, in the scientific, professional and political areas. This [...]

Social egg freezing (oocyte banking for anticipated gamete exhaustion). Ethical, practical and social problems

18 Sep

This text has two objectives: 1/to draw attention to an important issue in women’s health; and 2/to help train health professionals by providing evidence-based information about and criteria for what is called “social egg freezing.” Why don’t we extract eggs or ovarian tissue from women who are still young and then freeze and store them [...]

“Dr Cholesterol” against the “British Medical Journal”. Do not measure your cholesterol, be happy

26 May

The British Medical Journal has had problems with two papers about primary prevention of coronary artery disease (heart disease). Both papers have data that demonstrate statins have no use in primary prevention for most patients. The British Medical Journal problems relate to power, money and censorship. In this text a teacher explain the situation to [...]

Too much medicine. Less is more

13 Feb

Too much of a good thing is bad. Too much of good thing may not be wonderful. You can have too much of a good thing as food and alcohol and the excess of either can make you fat or drunk. In medicine, in general, the motto should be “maximum quality, minimum quantity”. Because more [...]

Minimum data set in General Practice: definitions and coding

31 Jan

A minimum basic data set (MBDS) was designed and used in general practice. The most important purpose and need for establishing such a data set is to assist in the provision of patient care. MBDS is designed to meet common needs for many general practitioners. Minimum means that individual programmes or the GP are free [...]